And then there was one

That's it, no more Petri dishes filled with our maybe-babies anymore. Now all we have is to wait and to prep for cycle number two. There is one little hope sitting frozen while we await its genetic screening results - which at my age put it at a perfect coin toss of being our first healthy embryo or the last one in the discard line from our first cycle.

The final report - leaving us with 50/50 odds that we may have just banked our first healthy embryo.

There were a few wins, enough to justify carrying on: we now know that I definitely have eggs that can be successfully fertilized and can grow to blastocyst stage. And we now know more about how my body responds that my doctor can use to better tailor the next cycle to my unique profile. If this is a numbers game, we just need more numbers, and the only way I'll be getting that is by cycling more. At the same time, it's hard not to get down on myself. Was it horribly arrogant of me at 37 years old to think I could change lanes and decide to go the bio parenting route? And how will I keep up the pace at work while walking a journey that might take the rest of this calendar year?

I'm exhausted, overwhelmed, distracted, disappointed, and very much needing to get back onto my work laptop.

So far so good

We're down to 4 healthy embryos at Day 3: Cleavage stage. The embryos are progressing exactly as we'd been told to expect, but that doesn't make it any less terrifying. I've already been warned of the anticipated 50% drop-off from now until Thursday when we'll get our final growth update. Any embryos that have made it that far will undergo biopsy and cryopreservation, and then we've got to survive another two whole weeks before getting the biopsy results.

Our embryos' Day 3 report

It's insane to me that I'm supposed to just go to work and be a productive human being while our future child(ren) may or may not be progressing through the first few days of their existence. I understand that any traditional conception would leave the parents completely in the dark for this stage, but I don't think I was mentally prepared for these natural uncertainties. Nicolas and my future hangs in the delicate balance of an environmentally-controlled Petri dish. It's dizzyingly surreal.

Quite the news to mark seven years of marriage!

A small miracle

Today, a small miracle happened. For the first time since they were formed back when I was in utero in 1986, some eggs left my body alive. Six of them, to be exact. And of these, five were mature and got to be introduced to the most attractive hand-picked sperm cells from my favorite human. How amazing is that? Somewhere, right now, in some hidden lab in some fabulous petri dishes, the very first cell divisions of my future children may be happening.

Survived 33 injections - and not so much worse for the wear!

I'm scared to write any of this down because our next update is coming in less than 24 hours. By tomorrow, all the possible futures of those little petri-dish maybe-babies could go up in smoke. The only thing in my control is my attitude for retrieval cycle number two, which starts in just two days. That round of eggs is finally awakening after nearly four decades of slumber, and it's in my power to ensure they get exposed to the most well-rested, nutrient-rich, and stress-reduced environment possible. But right now those poor gals are being robbed of their good night's sleep by my curiosity over the happenings in a lab in downtown Oakland.

Made it to egg retrieval and fertilization day!

Holding on to two things at once can be incredibly hard: though tomorrow may prove this cycle's efforts were for naught, today was a small miracle. I got a taste of a world where a human life can be conceived in a lab. It's an extraordinary step towards women staking the same claim to bodily autonomy as men, where two humans can each enjoy creating a biological family together without one of them having to profoundly compromise their physical well-being. (Of course, in a world where the external uterus is still relegated to animal research and is only currently being developed to help preemies, a woman must still sign up for the nine month ordeal, but in a place like America where this is thoroughly regulated, that woman doesn't have to be mom: she can be someone who's signed up voluntarily, who's passed physical and psychological screenings, who's had a proven track record of uncomplicated pregnancies, who'll be guaranteed good medical care, and who'll be compensated fairly for her efforts.) What a remarkable future.

It's ironic in a time where women's reproductive rights are so endangered that I am getting to explore such privilege. But, despite the legal and political challenges ahead, as someone who believes profoundly in the potential good in new technologies, I'm so excited for what the future could hold for the women of our children's generation.

Turns out

Off to a good start, physically. Mentally, on the other hand...

Turns out that an egg retrieval cycle is tough - really tough - only not at all in the way I’d anticipated. My body feels fine, perfectly fine, other than the sleep deprivation. I haven’t gained weight. My injections haven’t really hurt or bruised; they weren’t even stressful. My blood draw yesterday went beautifully. But I cannot get out of my head.

It doesn’t make sense that I’m so stressed about how my follicles may be progressing. (Some are, some aren’t.) My heart isn’t set on a baby. More than the outcome, the uncertainty around it is keeping me up at nights and killing my daytime focus. Nicolas and my life path will be profoundly impacted by these retrievals, one way or another. It feels like it’s all on me, yet it’s so out of my control.

I can take all the prenatal vitamins, track all my health metrics, read every article, and listen to every MD who made a fertility podcast, but no amount of studying will help me ace this test. I am so out of my depth. This egg retrieval exercise forces me to grapple with my own mortality: I’m playing with a biological system that’s on its last leg, the first in what will be a steady procession of them. Aging feels so abstract and impossible until you actually start to live it.

A big day on multiple fronts

Yesterday was a big day on multiple fronts:

In the personal sphere, it was first day I began any sort of fertility meds, at long last! I'm still only on the oral stage, and don't feel any impact yet, but at least things are getting a little more real.

On the professional front, we introduced the world to our first clinical trial participant who, despite some setbacks, is still enjoying being Neuralink's first telepathic human. And the world tuned in. I can't say I'm disappointed by the response. Even one of our most infamous online academic haters couldn't deny the accomplishments we (the engineers and scientists, not Mr. Musk, heaven forbid he see any positive coming from that man) demonstrated. All in all, a solid day. Just a pity I'm so deep in the weeds of confusing computing infrastructure that there isn't really a moment to step back and savor it. Maybe dumping these images here will give me something to come back to one day when I can breathe again and finally reflect on the magic I'm helping make happen.

We've finally delivered and the world is watching.

Let's get this started already

This is the big week: some time before next weekend, I anticipate getting the green light to start taking my (oral) priming meds to get me ready for the first egg retrieval cycle - finally. It's been two months of waiting, of countless hours speaking with my insurance company, my HR, and my fertility clinic to figure out what we're signing up for financially. I'm loaded up with nearly a dozen different daily+ vitamins that are all supposed to improve egg equality. I've learned about my ("highly impressive" per doctor's description, thank you very much) genetic profile and can sit secure in the knowledge that Nicolas and I can't make an embryo with any known single-gene disease. I've survived two (surprisingly easy) months off the pill. I've got a cabinet and a fridge drawer filled with more meds than I've probably taken over the past decade. I've peed onto and into way more things than I'd care to all for cycle tracking. Those sad little suppressed follicles from back in January are now (an approximately equal number of) plump and normal looking follicles per my latest ultrasound. We keep on coming round to the same conclusion: I'm on the edge, but am still technically clinging on to "totally normal fertility" by all metrics that we can measure before pumping me full of hormones and stabbing my ovaries for an egg hunting expedition.

The hormone screens, the cycle tracking, and the mountains of meds mean it's nearly go-time.

This is going to suck. At least that's what I'm expecting. I'm incredibly curious as to just how much. I've heard the more follicles you have, the worse this all feels, and I'm wondering if I may have hit the sweet spot where I've still got enough for our doctor to be quite optimistic about outcomes but not so many to feel like death warmed over by the time all's said and done. And let's hope this isn't all too awful because I'm signing up for the frequent flyer pass. It turns out my health coverage is incredibly generous: the first cycle is just a few thousand and every subsequent cycle within the calendar is free. With that in mind, at my age, why wouldn't we take a couple rides on this merry-go-round? Some extra up-front suffering to give ourselves the best odds of a healthy baby makes sense.

It's just such a mind f*ck (excuse the language) to have to dive in knowing there's no guarantee (other than pain and far too many blood draws). Will we get some embryos? Probably, but not for sure. The only certainty is that I'll undergo my first surgery complete with IV and general anaesthesia. And I may come out the other side with nothing more than the satisfaction of having tried. I hate that so much.

For better or worse, I just cannot wait to be on the other side.

Birthday princess

No more counting in months when we bump into fellow dog owners and are asked her age: this little lady just turned one today!

Happy birthday to you!